Honestly, the one thing I would do is get rid of the playoff and eliminate the potential for it to exist in the future. Heck, I'd even institute a 2 vs. 3 with 1 getting a bye game if that would prevent further corruption of what we have now. I mean look at some posts, we have suggestions for a 16! team (because LSU and UCF deserve a shot at the title...) or 32 team playoff. The BCS already diminished the bowls, and this won't end until the regular season, and what I believe makes college football special, is far less important. The Saints lost a huge game in the regular season, and in the end I was like, oh well they still have to win in the playoffs no matter what. The Alabama/Auburn game mattered so much because it actually meant something beyond seeding.
Otherwise, 4Q's suggestion is pretty good, but I'd probably simplify it a bit. I'd just have a minimum amount of time between plays, which would be determined to be minimal time required to make substitutions. So, there's no gaming of the system, just enough time for either team to substitute if they need to. I'd drop that requirement with 2 minutes to go in each half, and revert to current rules.
I think GreatDanish is on the right track to. It's just plain stupid to keep adding games, but not adding players. Injuries do happen, supposedly we care about the health of players, but we pretend they can play more and more games with no adverse consequences. That's absurd. I know going back to 105 would be a radical change, but I'd at least like to see it go to 26/90 and work it's way up from there. Ultimately, 28/100, with the SEC getting rational and upping the signing limit to 30 would be fairly good to me, and by adjusting the limits in that manner, it would eliminate some of the concern with so called over-signing.