The US squad went into the game with an offensive strategy in mind according to interviews the night before. After the early goal, they decided to pull back and play like they did against Italy 2 years ago. The US won 1-0 by playing this type of box defense (though they pressed Italy in the corners, where they seemed to give Ghana too much space).
But the key to that defense is having the risk of counter-attack to keep an offense from committing everyone to the attack. When the US lost Altidore, they lost their speed. He is the only burner that the US team has - a player who can leave the other team in his wake as he brings the ball up the field before passing off to one of our strikers.
That is why Ghana had so much success against the US - they were not afraid of the US counter. The US now has to score off of set plays run off of free kicks and corners. This is the strength of this team, but they will get few chances if they play as poorly in the midfield as they did against Ghana. That was mostly a result of their choice to keep Bradley back on defense, but it could have, and probably should have, cost the US that game.
Defensively, I don't think that the US will play soft on the edge again. It can work against Ghana without a dominant striker, but not against Portugal or Germany.