https://sports.yahoo.com/cardinals-...agnosed-with-pancreatic-cancer-022721659.html
He's 83, and panc is a virtual death sentence.
Here's hoping.
He's 83, and panc is a virtual death sentence.
Here's hoping.
It's what took out my mother, at exactly my age. I had a good friend call and tell me the other day that he had been dxed. He's hoping to make it to the end of the year, so he can close out his practice in an orderly fashion. OTOH, I do have one friend who apparently is going to beat it. Remarkably, he beat prostate cancer around 7-8 years ago. In his case, it started in the duct end and caused symptoms immediately, so they caught it in the gland sack. Some years ago, I had another friend where they caught it there, as they did Ginsburg. It still got him, but it took around four years instead of <6 months...https://sports.yahoo.com/cardinals-...agnosed-with-pancreatic-cancer-022721659.html
He's 83, and panc is a virtual death sentence.
Here's hoping.
It's what took out my mother, at exactly my age. I had a good friend call and tell me the other day that he had been dxed. He's hoping to make it to the end of the year, so he can close out his practice in an orderly fashion. OTOH, I do have one friend who apparently is going to beat it. Remarkably, he beat prostate cancer around 7-8 years ago. In his case, it started in the duct end and caused symptoms immediately, so they caught it in the gland sack. Some years ago, I had another friend where they caught it there, as they did Ginsburg. It still got him, but it took around four years instead of <6 months...
I'm at risk for the first two, with my mom's case. The second, I lost my brother and a first cousin to. Of the first two cancers, I'd select the second...I know we say this every time, but three things I absolutely do not want:
a) pancreatic cancer
b) glioblastoma multiformae
c) bone cancer
Catching it is almost to a large degree the result of how concerned one is to go to the doctor because (obviously what I hear as I have no firsthand experience) the presentation in most cases is someone thinks they pulled a muscle so they just take NSAIDs or tylenol.
I had one co-worker in his mid-40s. Vibrant, active guy, took care of himself, animal lover. Six weeks from diagnosis to death. And my former BIL lost out to it two years ago this week. They gave him 8 months, and he made it almost 18, but his quality of life was almost nonexistent. He was an active Vo Tech teacher at the school. One day he would be like absolutely nothing was wrong with him (other than maybe a little jaundice). The next three days, he wouldn't even move because it hurt so bad.
To those 3 I would add, d) Alzheimer's. A horrible, drawn-out disease that my dad had.I know we say this every time, but three things I absolutely do not want:
a) pancreatic cancer
b) glioblastoma multiformae
c) bone cancer
Catching it is almost to a large degree the result of how concerned one is to go to the doctor because (obviously what I hear as I have no firsthand experience) the presentation in most cases is someone thinks they pulled a muscle so they just take NSAIDs or tylenol.
I had one co-worker in his mid-40s. Vibrant, active guy, took care of himself, animal lover. Six weeks from diagnosis to death. And my former BIL lost out to it two years ago this week. They gave him 8 months, and he made it almost 18, but his quality of life was almost nonexistent. He was an active Vo Tech teacher at the school. One day he would be like absolutely nothing was wrong with him (other than maybe a little jaundice). The next three days, he wouldn't even move because it hurt so bad.
Been there, done that.To those 3 I would add, d) Alzheimer's. A horrible, drawn-out disease that my dad had.
Summary
Cancer stem cells promote neoplastic growth, in part by deregulating asymmetric cell division and enhancing self-renewal. To uncover mechanisms and potential therapeutic targets in glioma stem cell (GSC) self-renewal, we performed a genetic suppressor screen for kinases to reverse the tumor phenotype of our Drosophila brain tumor model and identified dCdk5 as a critical regulator. CDK5, the human ortholog of dCdk5 (79% identity), is aberrantly activated in GBMs and tightly aligned with both chromosome 7 gains and stem cell markers affecting tumor-propagation. Our investigation revealed that pharmaceutical inhibition of CDK5 prevents GSC self-renewal in vitro and in xenografted tumors, at least partially by suppressing CREB1 activation independently of PKA/cAMP. Finally, our TCGA GBM data analysis revealed that CDK5, stem cell, and asymmetric cell division markers segregate within non-mesenchymal patient clusters, which may indicate preferential dependence on CDK5 signaling and sensitivity to its inhibition in this group.
Graphical Abstract
You just reminded me of the first patient whose blood I ever drew who had that. It was one of the most bizarre things I've ever experienced.To those 3 I would add, d) Alzheimer's. A horrible, drawn-out disease that my dad had.
I'm hoping so.
I'm probably doomed with the only question being "what kind."I'm at risk for the first two, with my mom's case. The second, I lost my brother and a first cousin to. Of the first two cancers, I'd select the second...
Well, we all die of something. If it's not CAD or stroke, then it's likely going to be cancer. Those two syndromes cover the vast majority of deaths. After than, it drops way down to 6% of deaths from accidents and almost that percentage at just under 6%. (Looked it up recently.) So, everybody's family tree is going to look gruesome. It's when those ages start to be in the 30s, 40s and 50s, you start to worry about genes. It's normal if they're in the 70s and 80s...I'm probably doomed with the only question being "what kind."
On my Dad's side of the family - his Dad's family had nine total siblings. Two were murdered and all of the other seven died of some form of cancer (lung for the smokers, prostate for one uncle, and my grandfather was so consumed they couldn't figure out where it had begun nine years earlier). Dad's mom's side - one brother had a heart attack and the other three kids all died of cancer in their mid-70s.
On Mom's side - her Mom died of a Triple A at 87, her Dad had a cerebral hem at 76. Mom's sister died of a heart attack at 74 a few years ago.
Oh.....and Dad had temporal arteritis and a stroke and his brother had a stroke (though both have recovered).