Unless the B12 has a sea change, I don't see that happening.
Check out the link below.
Last year, the best B12 defense, Iowa State, ranked #37 of 130 FBS teams. Seven SEC defenses ranked higher than that. Five of them were in the Top 20. The B12 conference champs ranked #101. Only two SEC teams were worse than that, and other than when they played each other, neither won a conference game.
Half of the B12 ranked worse than #70. Almost a third of the conference was worse than #90.
So I may or may not be right that B12 defenses haven't seen a skill set like Jalen's. But suppose I'm wrong, and they have seen it. That doesn't mean they can stop it.
Jalen Hurts has a long track record of torching defenses of the level fielded by the B12 last year. After doing the research, I'm more confident than before that he will light up those defenses like a Roman candle.
His problem is that, against a Top 10 defense, he has struggled mightily....to the point of being somewhere between ineffective and an outright liability.
But we have no reason to believe he will face anything remotely close to a D of that caliber until the playoff, assuming OU makes it to that point (FWIW, I think they will). Which brings me back around to my original point.
https://www.sports-reference.com/cfb/years/2018-team-defense.html