I'm a big fan of giving your backups meaningful playing time - even when the game is not decided and especially if the starters are struggling to get things going. Coach Bryant used to do this and sometimes the 2nd unit would come in and give the team a lift and seize the momentum. This also gave the coaches time to talk with the starters and "coach them up" and gave the guys a chance to catch their breath and refocus, if necessary.
More substitution also provides valuable experience for your backups. They're ready to go later in the season if called upon due to injury or other issues. And if a backup knows he's going to be playing some, he's going to work harder and prepare better for the game, something that benefits everyone.
And last, but not least, next year, the guys who are backups this year will be ready to step up because they have game experience. It builds continuity. It builds teamwork. It builds confidence. And it develops leadership. It might also reduce the impact of players hitting the portal because they aren't getting playing time.
As CB4 said - the next game I coach will be the first game I coach - but I'd get the backups more playing time and give them a chance to show what they can do throughout the game, not just once the outcome is decided.