COVID-19: Medical and Scientific Information

[NationalTitles18]

Coronavirus blood-clot mystery intensifies

Research begins to pick apart the mechanisms behind a deadly COVID-19 complication.

www.nature.com

 

[NationalTitles18]

A question going through my mind:

What role are ACE2 serum antibodies thought to have in relation to COVID-19 manifestations? If those infected are producing these antibodies in response to infection, or perhaps already have them prior to infection, could this explain COVID toes (digital ischemia and vasculopathy), hypercoagulation, endothelial injury and some other manifestations of the disease?

The first link:
Quote: Angiotensin-converting enzyme (ACE) 2, a homolog of ACE, converts angiotensin (Ang) II into Ang(1-7), and the vasoprotective effects of Ang(1-7) have been documented. We explored the hypothesis that serum autoantibodies to ACE2 predispose patients with connective tissue diseases to constrictive vasculopathy, pulmonary arterial hypertension (PAH), or persistent digital ischemia.

https://arthritis-research.biomedcentral.com/.../ar3012

The second link:
Quote: The aim of the present study was to test the hypothesis that the activation of the angiotensin-converting enzyme (ACE)2/angiotensin-(1-7)/Mas receptor axis by use of a novel ACE2 activator (XNT) would protect against thrombosis....Thus, a decrease in thrombus ACE2 activity is associated with increased thrombus formation in SHR. Furthermore, ACE2 activation attenuates thrombus formation and reduces platelet attachment to vessels.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811560/

 

[TIDE-HSV]

Important - "re-positive" patients found not to be infectious...

Bloomberg

 

[TIDE-HSV]

Important - "re-positive" patients found not to be infectious...

Bloomberg

They may be able to put those sailor back aboard...

 

[4Q Basket Case]

Important - "re-positive" patients found not to be infectious...

Bloomberg

I was just going to post that....this is huge for the effectiveness of a vaccine.

Also for the development of better tests. Since the existing test can't tell the difference between a live virus and fragments of dead ones, it effectively generates a lot of false positives -- not good for anybody.

 

[TIDE-HSV]

I was just going to post that....this is huge for the effectiveness of a vaccine.

Also for the development of better tests. Since the existing test can't tell the difference between a live virus and fragments of dead ones, it effectively generates a lot of false positives -- not good for anybody.

It also explains some of the "false" negatives. We know so little about the disease, it's possible that the body's process of clearing the remnants of the virus are intermittent, in bursts, depending on functions we are as yet unaware...

 

[NationalTitles18]

Coronavirus: Immune clue sparks treatment hope

Better understanding of Covid-19's impact on the immune system gives hope an existing drug might aid recovery.

www.bbc.com

 

[NationalTitles18]

How a fitness class made 112 people sick | CNN

South Korea's aggressive testing and contact tracing program has given the country remarkable control of Covid-19, with the ability to respond quickly to new outbreaks, writes Kent Sepkowitz

www.cnn.com

 

[Tidewater]

This is a month old, but Oxford University study indicates a vaccine might be available as early as September.
In Race for a Coronavirus Vaccine, an Oxford Group Leaps Ahead

This seems like a hopeful sign.

 

[TIDE-HSV]

Hong Kong has the answer...

Vox

 

[NationalTitles18]

More research points toward masks as helpful.

(PDF) Association of Country-wide Coronavirus Mortality with Demographics, Testing, Lockdowns, and Public Wearing of Masks

PDF | Background. Wide variation between countries has been noted in per-capita mortality from the disease (COVID-19) caused by the SARS-CoV-2 virus.... | Find, read and cite all the research you need on ResearchGate

www.researchgate.net

 

[TexasBama]

Hong Kong has the answer...

Vox

We have had the answer before

 

[92tide]

We have had the answer before

View attachment 8320

you notice they didn't use a picture of uga

 

[TexasBama]

you notice they didn't use a picture of uga

II'm sure they wanted to show a more sophisticated crowd

 

[TIDE-HSV]

II'm sure they wanted to show a more sophisticated crowd

There is a notable difference between the grads of the two schools...

 

[TexasBama]

There is a notable difference between the grads of the two schools...

Also, Heisman was still coach at Tech. I would think they were a pretty good team.

 

[TIDE-HSV]

Another use for cannabis? (May be bias involved.)

CBD

 

[NationalTitles18]

May be bias involved

Precisely why I stayed silent on it, although there is a basis for the plausibility since several cannabinoids are known anti inflammatories and it's at least possible they could modulate the inflammatory "phase" of the disease. Mrs. NT17 got a good laugh the other day speculating cannabis as the cure and the pearl clutching back home.

ETA: The last bit was a social observation and not intended as a political statement.

 

[TIDE-HSV]

Precisely why I stayed silent on it, although there is a basis for the plausibility since several cannabinoids are known anti inflammatories and it's at least possible they could modulate the inflammatory "phase" of the disease. Mrs. NT17 got a good laugh the other day speculating cannabis as the cure and the pearl clutching back home.

I thought it was worth throwing out there FWIW, with the notation because it's being funded by pro-cannabis sources. Also, if it really reduces your ACE2 receptors by 70%, that's not without consequences. If it blocks the virus spikes' being able to attach to the receptors, then that's a different story...

 

[NationalTitles18]

I thought it was worth throwing out there FWIW, with the notation because it's being funded by pro-cannabis sources. Also, if it really reduces your ACE2 receptors by 70%, that's not without consequences. If it blocks the virus spikes' being able to attach to the receptors, then that's a different story...

Yep. Not criticizing the post. I was just waiting for more data. Hard to NOT get a biased source on cannabis research, especially in the US. (I know this was in Canada)