It's Time to End the "War on Drugs"

Crimson1967

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Nov 22, 2011
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Of nine drug decriminalization or legalization measures on state ballots last night—including two addressing hallucinogens and one covering all illegal drugs—not a single one failed. These were decisive victories, too, not close calls. And unlike some previous waves of pro-marijuana votes, which were concentrated in predictable areas, successful anti–drug war measures in 2020 spanned a diverse array of states.
Mississippi was one state that approved medical marijuana but now the state Supreme Court has thrown it out. But it seems to be more of a procedural issue of how the vote got on the ballot to begin with.

 

JDCrimson

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Feb 12, 2006
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So in Alabama, we easily approve alcohol to go but struggle with passing medical Marijuana. Grandma I've says after approving alcohol to go, we are just keeping up with the times...

The moral, logical, and religious conflicts of the Republican Party knows no bounds.
 

MobtownK

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Nov 20, 2004
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Ending this failed "war on drugs" will actually save and improve lives.

I wonder what benefits it would have in microdoses instead of the mood suppressors commonly used. The article is about 8 hr sessions, but it would be interesting to see the results of a prolonged microdoses.

Burning man? Hell it was at bluegrass festivals in Alabama in the early 2000s... burning man just gave it name recognition.
 
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NationalTitles18

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I wonder what benefits it would have in microdoses instead of the mood suppressors commonly used. The article is about 8 hr sessions, but it would be interesting to see the results of a prolonged microdoses.

Burning man? Hell it was at bluegrass festivals in Alabama in the early 2000s... burning man just gave it name recognition.
It appears that in the study, as designed, microdosing was not as effective. It may be that prolonged use of small doses, especially combined with psychotherapy, may be effective or that those with milder PTSD may benefit from smaller doses over a prolonged period. Obviously, this type of study is in its infancy and more study is needed.


Quote:


The primary outcome was change in total scores on the the Clinician-Administered PTSD Scale–IV (CAPS-IV) 1 month after the second session of MDMA-assisted psychotherapy.


In the intent-to-treat (ITT) set, the active-dose groups demonstrated the largest reduction in PTSD symptoms at the primary endpoint. The mean changes in CAPS-IV total scores were −26.3 with the 125-mg dose and −24.4 with the 100-mg dose, compared with −11.5 with the 40-mg dose. However, the results did not reach statistical significance.


In the per protocol (PP) set, there was a significant main effect in change of CAPS-IV total scores at the 125-mg dose (−37.0; P = .01) and a trend toward significance with the 100-mg dose (−24.4; P = .10), compared to 40-mg dose (mean change, −4.0).


"Although significant group differences were detected only in the PP set for the primary outcome, over half of participants in the ITT set who received active MDMA doses reached a 30% or greater drop in CAPS-IV total scores compared to 16.7% in the 40 mg group," the investigators note in their report.


After the third MDMA session, both the 100-mg and the 125-mg dose groups showed further reductions in CAPS-IV scores, "providing evidence that an additional session significantly improved PTSD outcomes," they note.


"Importantly," they write, the gains were maintained over 12 months after all groups had received active doses of MDMA, with 76% of patients no longer meeting the criteria for a diagnosis of PTSD.
 
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