No, it does matter. In the history of this nation, a Democrat has never won the EC while losing the popular vote. In contrast, the system has benefited a Republican 5 of 6 times in our history. And that 6th example (Adams in 1824) benefited the direct political precursor to the Republican party.
Now, the demographics of this country are vastly different in the 2000's (Bush and Trump) from the 1800's (Adams, Hayes, Harrison), but it's simply dishonest to dismiss complaints about the EC as sour grapes. It is mathematical fact that the EC weighs the votes of certain Americans more than others. And the farther we move from the Founders' agrarian ideal, the more apparent that systemic bias becomes. Some people will support that bias because it benefits them, but it absolutely exists.